I don't know what to do.
I don't know what to do. (该怎么办呢?)
Don't worry, I'll help. (别担心，我来帮你。)
I'm at a loss as to what to do. (我真不知该怎么办才好。)
I'm unable to decide for myself. (我一个人决定不了。)
What shall I do? (怎么办?)
我该怎么办?
What am I supposed to do? *be supposed to “计划做……”。
What am I supposed to do? (我该怎么办?)
I don't know. Just relax, I'll help you. (我也不知道。放松点儿，我会帮助你的。)
What am I going to do?
What should I do?
这下可麻烦了。
We are in trouble.
We can't finish our proposal in time. (我们不能按时完成计划了。)
We are in trouble. (这下可麻烦了。)
We're in big trouble. *进一步强调不知如何是好的心情。
那很麻烦。http://huncy88.blog.163.com/blog/static/18133716220142425933601/
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